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KMID : 0032220090210040409
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Annals of Dermatology
2009 Volume.21 No. 4 p.409 ~ p.412
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Coexistence of Amelanotic Melanoma and Liposarcoma
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Jeong Taek-Jo
Lee Eun-Ju
Haw Sik
Shin Min-Kyung
Haw Choong-Rim
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Abstract
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An amelanotic malignant melanoma is characterized by little or no pigment. It is frequently misdiagnosed because it is a rare entity in general, and because of its unusual clinical features. Liposarcoma is one of the most common adult soft tissue sarcomas. We encountered a case of amelanotic melanoma with a concurrent liposarcoma. A 68-year-old man presented with a single, 1.5×1.5 cm round erythematous, eroded nodule on the left heel. A biopsy specimen showed atypical, pleomorphic tumor cells with little melanin pigment. The tumor cells were positive for S-100, HMB-45 and negative for cytokeratins. These findings were consistent with amelanotic melanoma. On positron emission tomography/computed tomography (PET/CT), a hypermetabolic lesion was found in the left buttock. This lesion was excised and diagnosed as a well-differentiated liposarcoma. An association between sarcomas and other primary malignancies has been reported. However, an association between melanoma and liposarcoma is rare.
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KEYWORD
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Amelanotic melanoma, Liposarcoma
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